Compound Profiles
NAD+ Research: Cellular Energy, DNA Repair, and Sirtuin Pathways
Healthy Aminos Research Team · · 7 min read
Molecular Profile
[NAD+](/peptides/anti-aging/nad-plus) (nicotinamide adenine dinucleotide) is a coenzyme present in all living cells. MW: 663.43 Da (CAS: 53-84-9). Formula: C21H27N7O14P2. It exists in oxidized (NAD+) and reduced (NADH) forms and participates in over 500 enzymatic reactions.
NAD+ serves as an essential cofactor for three major enzyme families: sirtuins (SIRT1-7, NAD+-dependent deacylases), PARPs (poly-ADP-ribose polymerases involved in DNA repair), and CD38/CD157 (ectoenzymes involved in calcium signaling).
Published Research
### NR Supplementation Trial
[Martens et al. (2018)](https://pubmed.ncbi.nlm.nih.gov/29599478/) conducted a randomized, placebo-controlled, crossover trial of nicotinamide riboside (NR, an NAD+ precursor) supplementation in healthy middle-aged and older adults. The study reported that NR elevated circulating NAD+ metabolites by approximately 60% and was well-tolerated over the study period.
### NADPARK Study
[Brakedal et al. (2022)](https://pubmed.ncbi.nlm.nih.gov/35235774/) published results from the NADPARK study — a phase 1 randomized clinical trial of NR supplementation in participants with Parkinson's disease. The study's primary endpoint was safety and tolerability. The authors reported that NR increased cerebral NAD+ levels as measured by magnetic resonance spectroscopy.
### NMN Supplementation Trial
[Kim et al. (2023)](https://pubmed.ncbi.nlm.nih.gov/36797393/) published a randomized, double-blind, placebo-controlled trial of NMN (nicotinamide mononucleotide, another NAD+ precursor) in middle-aged adults. The study reported increases in blood NAD+ concentrations and examined walking speed and grip strength as functional endpoints.
Research Context
NAD+ research has generated significant interest due to documented age-related decline in NAD+ levels across multiple tissues. The field has progressed from in vitro and animal model studies to human clinical trials examining NAD+ precursor supplementation. Direct NAD+ supplementation is also under investigation.
NAD+ is supplied as a lyophilized powder in 500mg vials. Store at -20°C. Also explore [Epithalon](/peptides/anti-aging/epithalon) and [MOTS-c](/peptides/anti-aging/mots-c) in the longevity research category.
*All Healthy Aminos products are for research use only. Not for human or animal consumption. Not FDA approved.*